解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Human natural killer (NK) cells express on their surface several members of the C-type lectin family such as NKR-P1, CD94, and NKG2 that are probably involved in recognition of target cells and delivery of signals modulating NK cell cytotoxicity. To elucidate the mechanisms involved in signaling via these receptors, w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050267
更新日期:1997-01-01 00:00:00
abstract::The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050311
更新日期:1997-01-01 00:00:00
abstract::Sixteen microsatellite markers, including two described here, were used to construct a high-resolution map of the 1q32 region encompassing the regulator of the complement activation (RCA) gene cluster. The RCA genes are a group of related genes coding for plasma and membrane associated proteins that collectively contr...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050224
更新日期:1997-01-01 00:00:00
abstract::The guppy, Poecilia reticulata, a teleostean fish of the order Cyprinodontiformes, has been used extensively in studies of host-parasite interactions, courtship behavior, and mating preference, as well as in ecological and evolutionary genetics. A related species was among the first poikilotherm vertebrates to be used...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00186602
更新日期:1996-01-01 00:00:00
abstract::A healthy adult having no serologically detectable HLA class I A locus antigens was identified. The parents of the individual are consanguineous. Results of a family study indicated that the individual is homozygous for the B46-Cw1-DR8.1 haplotype, which was shown to be positively associated with A*0207 in our previou...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00186597
更新日期:1996-01-01 00:00:00
abstract::Because of the role major histocompatibility complex (MHC) class I b molecules may play during mouse embryonic development, we thought it would be interesting to search for additional MHC class I b molecules that might be expressed in preimplantation embryos, and in particular in the trophoblastic lineage. We therefor...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050178
更新日期:1996-01-01 00:00:00
abstract::The factors which influence expression of autoimmune disease in the central nervous system are still poorly understood. We determined the characteristics of experimental autoimmune encephalomyelitis (EAE) in twelve different inbred strains of mice using either mouse spinal cord homogenate or synthetic peptides as the ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602559
更新日期:1996-01-01 00:00:00
abstract::The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02440994
更新日期:1996-01-01 00:00:00
abstract::Using cDNA hybridization selection techniques, we identified seven new genes in a 280 kilobase YAC covering the HLA-F locus. The new genes were mapped back to the YAC by a combination of optical restriction mapping and pulse field gel electrophoresis. Northern analysis of individual clones demonstrated the presence of...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02660056
更新日期:1996-01-01 00:00:00
abstract::Alignment of class I-hybridizing cosmids from an R21 (AlBlDlEugrc+) genomic DNA library gave two contigs: one [150 kilobases (kb)] encompassed the E/C region, or a large part thereof, and the other (110 kb) contained the grc region which has genes influencing resistance to chemical carcinogens (rcc), fertility (ft), a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602652
更新日期:1996-01-01 00:00:00
abstract::The inbred strain STS/A exhibits a higher proliferative response in the mixed lymphocyte culture (MLC) to stimulator cells of all 11 tested inbred mouse strains with 10 different major histocompatibility complex (MHC) haplotypes, as well as to stimulation with IL-2 than does the strain BALB/cHeA. However, alloantigen-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602654
更新日期:1996-01-01 00:00:00
abstract::The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassical MHC class I genes. A distinct family of MHC class I genes has been recently identified within the human MHC class I region. The MICA (MHC cl...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602779
更新日期:1996-01-01 00:00:00
abstract::Severe combined immune deficiency (scid) mice are assumed to have two types of abnormalities: one is high radiosensitivity and the other is abnormal recombination in immunoglobulin and T-cell receptor genes. The human chromosome 8 q1.1 region has an ability to complement the scid aberrations. Moreover, the localizatio...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050159
更新日期:1996-01-01 00:00:00
abstract::Lentinan, a beta-1,6;1,3-glucan, is tumor-specific for transplantable mouse solid-type tumors and it also stimulates the production of acute phase proteins (APPs). The APP response to lentinan is of the delayed type (DT-APR) and differs from that to lipopolysaccharide, which is acute. We found that the responses were ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00587302
更新日期:1996-01-01 00:00:00
abstract::In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00172153
更新日期:1995-01-01 00:00:00
abstract::Retinoid X receptors (RXRs) are zinc finger-containing nuclear transcription factors. They belong to the nuclear receptor superfamily that contains retinoid receptors, vitamin D receptors, thyroid hormone receptors, and steroid hormone receptors as well as the so-called orphan receptors. We previously mapped all three...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00182317
更新日期:1995-01-01 00:00:00
abstract::Many immunoglobulin variable region (IgV) genes are present in the vertebrate genome and provide a basis for antibody diversity. IgV genes have been classified into distinct families according to DNA sequence similarity. Comparisons of VH and VL genes from two mammalian species (mouse and human) have led to the conclu...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188428
更新日期:1995-01-01 00:00:00
abstract::Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00172151
更新日期:1995-01-01 00:00:00
abstract::The characterization of genes involved in the generation of the immune repertoire is an active area of research in lower vertebrate taxa. The recombination activating genes (RAG) have been shown to be essential for V (D) J recombination of T-cell antigen receptor (TCR) and immunoglobulin (Ig) genes, leading to the gen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00191224
更新日期:1995-01-01 00:00:00
abstract::The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00178583
更新日期:1995-01-01 00:00:00
abstract::Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00179398
更新日期:1995-01-01 00:00:00
abstract::The only avian major histocompatibility complex (Mhc) genes thus far identified are from species of the relatively small order of Galliformes, while by far the largest order of Passeriformes (songbirds), containing some 60% of extant bird species, has not been studied at all in this regard. The Galliformes emerged mor...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00176443
更新日期:1995-01-01 00:00:00
abstract::Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00163991
更新日期:1995-01-01 00:00:00
abstract::The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00189229
更新日期:1994-01-01 00:00:00
abstract::A 280 kilobase (kb) contig was isolated from mouse genomic P1 and cosmid libraries, using as probes human cDNA and genomic DNA fragments that map in the interval between the second component of complement and tumor necrosis factor genes of the HLA complex. The clone contig demonstrates synteny of eleven mouse genes th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00171796
更新日期:1994-01-01 00:00:00
abstract::We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized on a melanoma by autologous cytolytic T lymphocytes. Probing cosmid libraries with a MAGE-1 sequence, we identified 11 closely related genes. The analysis of hamster-human somatic cell hybrids indicated that the 12 MAGE ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01246677
更新日期:1994-01-01 00:00:00
abstract::A graft-vs-host reaction (GVHR) develops after major histocompatibility complex (MHC)-compatible bone marrow-transplantation. In the genetic combination studied, B10.D2 donor cells differed from those of (DBA/2 x B10.D2)F1 mice for multiple DBA/2 minor histocompatibility antigens (mHAg) and minor lymphocyte stimulatin...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00241258
更新日期:1994-01-01 00:00:00
abstract::The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequence...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188786
更新日期:1994-01-01 00:00:00
abstract::Irradiation with UVB (290-320 nm) initiates a systemic immunosuppression detectable as suppression of contact hypersensitivity (CHS). We investigated susceptibility to UV suppression in reciprocal F1-hybrid and backcross mice derived from BALB/c (low susceptibility) and C57BL/6 (high susceptibility) inbred strains. CB...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00189969
更新日期:1994-01-01 00:00:00
abstract::Cosmid clones containing T-cell receptor Tcra V2 subfamily gene segments have been isolated from a BALB/c cosmid library and subjected to DNA sequence analysis. The V gene segments in the Tcra V2 subfamily differ from each other by 3%-7% at the nucleotide level and 5%-16% at the amino acid level. T-cell receptor Tcra ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188174
更新日期:1994-01-01 00:00:00
abstract::Genes encoding the horse (Equus caballus) T-cell receptor beta chain (TCRB) were cloned and characterized. Of 33 cDNA clones isolated from the mesenteric lymph node, 30 had functionally rearranged gene segments, and three contained germline sequences. Sixteen unique variable segments (TCRBV), 14 joining genes (TCRBJ),...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188177
更新日期:1994-01-01 00:00:00
abstract::The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00177825
更新日期:1994-01-01 00:00:00
abstract::Eleven new C4d genomic primate sequences of the fourth complement factor (C4) have been obtained. Seven of them belong to five species not yet explored for this gene: Pan paniscus (pygmy chimpanzee), Cercopithecus aethiops (green monkey), Macaca mulatta (rhesus monkey), Macaca fascicularis (cynomolgus), and Saguinus o...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00177822
更新日期:1994-01-01 00:00:00
abstract::Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic re...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00210476
更新日期:1993-01-01 00:00:00
abstract::We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German origin. The phenotype frequency of the TNFB*1 allele was significantl...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00222469
更新日期:1993-01-01 00:00:00
abstract::Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216831
更新日期:1993-01-01 00:00:00
abstract::Class II genes of the human major histocompatibility complex (MHC) are polymorphic. Allelic variation of the coding region of these genes is involved in the antigen presentation and is associated with susceptibility to certain autoimmune diseases. The DR region is unique among human class II regions in that multiple D...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216386
更新日期:1993-01-01 00:00:00
abstract::TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in both genes and, in this study, we have identified another polymorphic site within the ade...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216802
更新日期:1993-01-01 00:00:00
abstract::Stable cell surface presentation of HLA class I molecules requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and TAP2, which map in the major histocompatibility complex class II region. Alleles of each gene are derived from a combination of variable sites at...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00187452
更新日期:1993-01-01 00:00:00
abstract::The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216835
更新日期:1993-01-01 00:00:00